1s0i

Publication Abstract from PubMed
Sialidases are a superfamily of sialic-acid-releasing enzymes that are of significant interest due to their implication as virulence factors in the pathogenesis of a number of diseases. However, extensive studies of viral and microbial sialidases have failed to provide a comprehensive picture of their mechanistic properties, in part because the structures of competent enzyme-substrate complexes and reaction intermediates have never been described. Here we report these structures for the Trypanosoma cruzi trans-sialidase (TcTS), showing that catalysis by sialidases occurs via a similar mechanism to that of other retaining glycosidases, but with some intriguing differences that may have evolved in response to the substrate structure.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure
1S0I is a 1 chain structure of sequence from Trypanosoma cruzi. Full crystallographic information is available from OCA.

Reference
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